Study the pathogenicity of Providencia Vermicola in mice

P. vermicola is an opportunistic pathogen of human and animals. To estimate the pathogeneses P.vermicola in mice infected orally I/P with 1x108 CFU/ml).The histopathological changes at 24 hrs showed infiltration inflammatory cells apoptosis hepatocytes liver, around a congested blood vessel interstitial tissue kidney; lung revealed congestion vessels, alveolar emphysema; intestine appeared mononuclear mucosa layer hyperplasia goblet cells. In I/P, liver necrotic area granulomatous lesion formation, spleen depletion white pulp. The kidney dilatation bowman’s space vacuolation glomeruli. submucosa layers cells, also, interalveolar septa emphysema.